Rachel Bright and Daria Mochly-Rosen The Role of Protein Kinase C in Cerebral Ischemic and Reperfusion Injury
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چکیده
The Role of Protein Kinase C in Cerebral Ischemic and Reperfusion Injury Print ISSN: 0039-2499. Online ISSN: 1524-4628 Copyright © 2005 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Stroke doi: 10.1161/01.STR.0000189996.71237.f7 2005;36:2781-2790; originally published online October 27, 2005; Stroke. http://stroke.ahajournals.org/content/36/12/2781 World Wide Web at: The online version of this article, along with updated information and services, is located on the
منابع مشابه
The role of protein kinase C in cerebral ischemic and reperfusion injury.
BACKGROUND AND PURPOSE Stroke is a leading cause of disability and death in the United States, yet limited therapeutic options exist. The need for novel neuroprotective agents has spurred efforts to understand the intracellular signaling pathways that mediate cellular response to stroke. Protein kinase C (PKC) plays a central role in mediating ischemic and reperfusion damage in multiple tissues...
متن کاملNeurobiology of Disease Protein Kinase C Mediates Cerebral Reperfusion Injury In Vivo
Rachel Bright,1 Ami P. Raval,5 Jeffrey M. Dembner,2 Miguel A. Pérez-Pinzón,5 Gary K. Steinberg,2,3,4 Midori A. Yenari,2,3,4 and Daria Mochly-Rosen1 Departments of 1Molecular Pharmacology, 2Neurosurgery, and 3Neurology and Neurological Sciences, 4Stanford Stroke Center, Stanford University School of Medicine, Stanford, California 94305, and 5Cerebral Vascular Disease Research Center, Department ...
متن کاملInhibition of delta-protein kinase C protects against reperfusion injury of the ischemic heart in vivo.
BACKGROUND Current treatment for acute myocardial infarction (AMI) focuses on reestablishing blood flow (reperfusion). Paradoxically, reperfusion itself may cause additional injury to the heart. We previously found that delta-protein kinase C (deltaPKC) inhibition during simulated ischemia/reperfusion in isolated rat hearts is cardioprotective. We focus here on the role for deltaPKC during repe...
متن کاملInhibition of -Protein Kinase C Protects Against Reperfusion Injury of the Ischemic Heart In Vivo
Background—Current treatment for acute myocardial infarction (AMI) focuses on reestablishing blood flow (reperfusion). Paradoxically, reperfusion itself may cause additional injury to the heart. We previously found that -protein kinase C ( PKC) inhibition during simulated ischemia/reperfusion in isolated rat hearts is cardioprotective. We focus here on the role for PKC during reperfusion only, ...
متن کاملCandesartan Attenuates Ischemic Brain Edema and Protects the Blood–Brain Barrier Integrity from Ischemia/Reperfusion Injury in Rats
Background: Angiotensin II (Ang II) has an important role on cerebral microcirculation however, its direct roles in terms of ischemic brain edema need to be clarified. This study evaluated the role of central Ang II by using candesartan, as an AT1 receptor blocker, in the brain edema formation and blood-brain barrier (BBB) disruption caused by ischemia/reperfusion (I/R) injuries in rat. Methods...
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تاریخ انتشار 2005